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Salk scientists solve longstanding biological mystery of DNA organization

Researchers image 3D genome in nucleus of living human cell for the first time

LA JOLLA—Stretched out, the DNA from all the cells in our body would reach Pluto. So how does each tiny cell pack a two-meter length of DNA into its nucleus, which is just one-thousandth of a millimeter across?

The answer to this daunting biological riddle is central to understanding how the three-dimensional organization of DNA in the nucleus influences our biology, from how our genome orchestrates our cellular activity to how genes are passed from parents to children.








ChromEMT: Visualizing 3D chromatin structure and compaction of the human genome in interphase and mitotic cells


Horng D. Ou, Sébastien Phan, Thomas J. Deerinck, Andrea Thor, Mark H. Ellisman, Clodagh C. O’Shea

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